Home Add to Favorite Contact Submit  
           16 May, 2021

Category:  Press » Science


Replikins' FluForecast Software Pinpoints Change in Deadly Bird Flu Amino Acid Sequence In Humans

         Views: 1945
2006-06-06 04:56:18     

WHO and CDC spokespersons have recently announced that no significant worrisome sequence changes have been observed so far in H5N1 isolates from high mortality H5N1 Indonesian human cases (CIDRAP: Center for Infectious Disease Research and Policy News, May 24, 2006). Significant sequence changes are thought to be required for person-to-person transmission to occur, a necessary prerequisite for a human pandemic. Using new search technology, FluForecast® software (see www.replikins.com for background and data), Replikins, Ltd. has discovered that in fact, a change in the amino acid sequence has occurred: a recent single amino acid substitution, to be referred to as “Sub”, in an H5N1 virus protein, which may be significant because of the last time it was seen. The company detected the amino acid “Sub” and tracked the sequence in which it occurred back 49 years. Sub is absent from all earlier H5N1 back to H5N1’s first appearance in 1959, and is only present in the last two high-mortality influenza pandemics, of 1957 (H2N2) and 1968 (H3N2), which were responsible for millions of deaths, and in a recent, fortunately brief, outbreak of H7N7, with one human death. The company’s FluForecast® software found the Sub amino acid substitution in earlier swine H1N1 infections, but not in recent chicken H5N1 isolates, and only in recent human H5N1 isolates, and only in human cases in areas with high mortality. Sub is present in isolates from Vietnam and Indonesia human H5N1 cases. This substitution correlates with epidemiological evidence that suggests that human person-to-person ‘cluster’ transmission may already have occurred, although infrequently to date. Dr. Sam Bogoch, the company’s chairman, said that the sequence in which Sub occurs is a small virus peptide which the company has found to be conserved in H1N1, H2N2, H2N3, and H5N1, for 88 years, from 1917 to the present. The company has also found that an increase in concentration of peptides of this type in proteins is associated with rapid replication and epidemics. With use of the company’s FluForecast® software, for the first time, strain-specific quantitative protein correlations with epidemics have been observed. The rise in ‘Replikin Count’ (number of replikins per 100 amino acids), detected by the FluForecast software, has been found to be quantitatively correlated with and predictive in advance of the last three flu pandemics of the past century and the last three H5N1 epidemics from 1997 to the present. FluForecast® permits advance strain-specific warning of 1 to 3 years that an epidemic or pandemic is on its way, thus allowing greater time and more specificity in tailoring more accurate, potentially safer, synthetic influenza vaccines. Previous lack of information of the substituted structure of H5N1, which might be the agent of the next pandemic, has hindered attempts to produce appropriate vaccines. In addition, current egg- and cell-based methods produce vaccines which contain thousands of unwanted proteins which may produce undesirable side effects, take 6 to 9 months or more to make, and more time to test. Replikins Ltd. is now synthesizing several new synthetic flu vaccines and conducting initial trials. While a single substitution, alone, may not guarantee a pandemic, and the function of the substitution is not as yet known, the occurrence of the same substitution of amino acid “Sub”, at least as a marker in the last two high-mortality pandemics, in 1957 and 1968, its occurrence now only in humans, accompanied by high Replikin counts and high mortality rates, together may suggest, in contrast to previous more comforting assessments, that H5N1 is indeed on the path to a human pandemic. What finally determines if and when a full-force pandemic materializes is still unknown. “Replikins is working with several government and private institutions to test the company’s new synthetic vaccines” said Dr. Bogoch, Chairman of Replikins Ltd.

Specialized in: Replikins - Pinpoints - Deadly Bird Flu - Amino Acid
URL: http://www.replikins.com/
Print press release      Bookmark this page
Related Press releases 
The December Edition Of The Bridge, The Materials Science Newsletter From Rigaku, Is Now Online (Popularity: ): THE WOODLANDS, Texas - December 28, 2017 -- The latest edition of The Bridge, the materials science newsletter from Rigaku Corporation, is now available on the company’s global website. The Bridge presents current news and analysis techniques related to the latest developments in X-ray based materials science.News reports, articles and scientific papers related to X-ray diffraction (XRD), wavelength dispersive X-ray fluorescence (WDXRF), energy dispersive X-ray fluorescence (EDXRF), total reflection X-ray ...
Pace Environmental Clinic Study: Coast Guard Blocked Public Access to Information in Hudson Anchorage Controversy (Popularity: ): Pleasantville, NY - December 09, 2016 -- Government Officials Join Clinic Students in Asking Commandant to Withdraw Shipping Industry ProposalCharging that the the shipping industry is benefiting from the Coast Guard’s circumvention of its own procedures, including two major river studies and extensive consultation with outside experts and the public, the students of the Environmental Policy Clinic of the Dyson College Department of Environmental Studies and Science at Pace University ...
The Andean Sky God Website Has Expanded to Include the Voynich Manuscript (Popularity: ): July 18, 2013 – FORT LAUDERDALE, Florida – The Andean Sky God Website, originally created as an archeology site to demonstrate a strong connection between the Tiwanaku Empire and the Nazca Lines, has expanded in recent years to cover other historical mysteries. The latest investigation of Morten St. George, the site's founder, is now online and it concerns the world's most mysterious manuscript, a medieval document written in undecipherable code, ...
New Hallowell Shelving at A Plus Warehouse (Popularity: ): Indianapolis, Indiana - July 05, 2013 -- A Plus Warehouse is proud to announce a new item in the shelving line. The company is sure that this new item will easily become a customer favorite. This new item is the Deluxe Open and Closed Industrial Shelving.This item obviously falls under the industrial shelving line. Industrial shelving has always been an extremely powerful line at A Plus Warehouse. Industrial shelving is ...
GenScript Corporation has Installed the First BiacoreTM T200 Biosensor in the World (Popularity: ): PISCATAWAY, N.J,– GenScript Corporation and GE Healthcare Life Sciences China together held an opening ceremony on Dec 22nd 2010 in Nanjing China, to celebrate the successful installation of the first unit of BiacoreTM T200 instrument in the world. To an audience of primarily research scientists from both big pharma and academia, GE described the BiacoreTM T200’s excellent capabilities in label-free interaction analysis, while GenScript presented real life data the company ...

Press release home snapshot 

Related Business 
AlgoNomics (Popularity: ): Provides online, as well as on-site, tools for protein sequence analysis and structure prediction. Focused on the relationship between the amino acid sequence of proteins and their function.
Foods With Lysine (Popularity: ): Information and news on amino acid supplements and health matters relating to lysine and l-lysine and their effects with other similar proteins. Amino acids which cannot be produced by the body are called "essential amino acids". An amino acid is used by the body to produce protein.
Nematode Net (Popularity: ): Project at Washington University to sequence parasitic nematodes of humans, animals, and plants. Provides access to new gene sequence information, tools for analyzing nematode sequences, and brief information and photos of the species.
Natural Cure for Swine flu Prevention (Popularity: ): If you are looking for swine flu natural prevention then try our natural remedies for swine flu,herbal supplements for swine flu,ayurvedic cure for swine flu.Get free online consultation for swine flu information.
GuangdeTiancheng Chemical Co., Ltd. (Popularity: ): Manufacturer of dye intermediates including 1-amino-4-naphthalene sulfonic acid sodium, neville and winter's acid, copper sulfate, nickel sulfate.
W.M. Keck Foundation (Popularity: ): A protein and nucleic acid chemistry core facility that provides amino acid analysis, protein and DNA sequencing, peptide and oligonucleotide synthesis and mass spectrometry.
Stomach Flu (Popularity: ): The influenza virus, popularly known as “the flu” has plagued people of all ages and demographics since the beginning of time. With advances in modern science, treatments such as the flu shot have risen to prominence.
BioTools Incorporated (Popularity: ): Provides software tools to accelerate the research process: GeneTool for DNA sequence analysis, PepTool for protein sequence analysis, and ChromaTool for DNA sequence assembly.
DNA Baser Sequence Assembler (Popularity: ): DNA Baser Sequence Assembler is unique and revolutionary bioinformatics software for manual and automatic DNA sequence assembly, DNA sequence analysis, automatic sample processing, contig editing, metadata integration, file format conversion and mutation detection.
Maxim Health Systems Find a Flu Shot Clinic (Popularity: ): Locate flu shot clinics by zip code, area code, or state. Get information on who needs a flu shot and why its important for preventing complications.